Hormonal
Short-term administration of atypical antipsychotics (olanzapine and aripiprazole) induces insulin resistance in healthy subjects independent of weight gain, increased food intake, or psychiatric disease.
If you are prescribed olanzapine or aripiprazole, you may develop insulin resistance even if you do not gain weight or change your diet. This is a direct pharmacological effect on your tissues, not a result of your lifestyle. Monitoring blood sugar and insulin sensitivity is crucial, regardless of your body weight changes.
Importantly, the metabolic changes occur in the absence of weight gain, increases in food intake and hunger, or psychiatric disease, suggesting that AAPs exert direct effects on tissues independent of mechanisms regulating eating behavior.
Why this rating
Randomized, double-blind, placebo-controlled trial with euglycemic-hyperinsulinemic clamps (gold standard for insulin sensitivity), but small sample size (n=10 per group) and short duration (9 days).
Source
Antipsychotic-Induced Insulin Resistance and Postprandial Hormonal Dysregulation Independent of Weight Gain or Psychiatric Disease
Karen L. Teff et al. · Diabetes · 2013
DOI 10.2337/db13-0430
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