Research
Hormonal
Ethinyl Estradiol-Cyproterone Acetate (EE-CA) oral contraceptives significantly increase serum leptin and BMI in nonobese women with PCOS, despite improving hyperandrogenism.
EE-CA pills effectively lower testosterone in nonobese PCOS patients but may slightly increase body weight and significantly raise leptin levels. Patients should be aware of these metabolic changes while benefiting from improved menstrual cycles.
GoodQualifiesHIGH confidence
EE-CA did not have any significant effect on glucose tolerance, serum insulin levels, or insulin sensitivity, but it increased slightly the body mass index (P < 0.09) and significantly serum leptin concentrations (P < 0.001)... The slight increase of BMI coincided with a significant increase of serum leptin concentrations at 6 months of treatment with EE-CA.
Why this rating
RCT design, clear statistical significance for leptin increase.
Source
Metformin<i>Versus</i>Ethinyl Estradiol-Cyproterone Acetate in the Treatment of Nonobese Women with Polycystic Ovary Syndrome: A Randomized Study
Laure Morin‐Papunen et al. · The Journal of Clinical Endocrinology & Metabolism · 2003
DOI 10.1210/jc.2002-020997
rct · n=17Cited 182×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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