Hormonal
Genetic polymorphisms in circadian clock genes (specifically PER2, PER3, NPAS2, and CLOCK) interact with shift work environment to influence sleep duration, caffeine consumption, and adaptation levels.
Your ability to adapt to night shifts may be influenced by your genetics, specifically variations in clock genes like PER2, PER3, and NPAS2. While you cannot change your genes, understanding that your genetic makeup might make you more susceptible to sleep issues or caffeine dependence on nights shifts can help you proactively manage your sleep hygiene and caffeine intake.
polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models.
Why this rating
Genetic association study with significant p-values after correction, but observational nature limits causal inference.
Source
Shift Work in Nurses: Contribution of Phenotypes and Genotypes to Adaptation
Karen L. Gamble et al. · PLoS ONE · 2011
DOI 10.1371/journal.pone.0018395
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