Research
Hormonal
Store-Operated Calcium Entry (SOCE) is a critical mechanism for sustaining contractility during repeated contractions and contributes to long-term muscle remodeling by enhancing gene expression via NFAT.
High-repetition or endurance-style training may be necessary to engage SOCE pathways, which support sustained force and contribute to muscle remodeling. Ignoring this may limit adaptations related to fatigue resistance and fiber type switching.
GoodSupportsHIGH confidence
The main tasks for SOCE relies on the increased delivery of Ca2+ in the cytosol of the myofiber hereby supporting the requirement of high Ca2+ gradients under repeated contractions and to enhance Ca2+ sensitivity of myofilaments... SOCE has been shown to contribute significantly to enhanced gene expression via nuclear factor of activated T-cells (NFAT)
Why this rating
Review paper citing multiple studies on SOCE mechanisms.
Source
Ca2+-Dependent Regulations and Signaling in Skeletal Muscle: From Electro-Mechanical Coupling to Adaptation
Sebastian Gehlert et al. · International Journal of Molecular Sciences · 2015
DOI 10.3390/ijms16011066
narrative_reviewCited 181×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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