Research
Hormonal
Elevated skeletal muscle expression of myostatin, but not ubiquitin proteasome components, is a key molecular mechanism driving post-liver transplantation sarcopenia.
This finding suggests that post-transplant muscle loss might be driven by hormonal signals (myostatin) rather than just protein breakdown. While this is based on a very small group, it hints that future treatments might need to target these specific hormones to help patients regain muscle mass after surgery.
LimitedSupportsLOW confidence
Skeletal muscle expression of myostatin was higher and that of ubiquitin proteasome proteolytic components lower post-OLT than in controls.
Why this rating
Very small sample size for the molecular analysis (n=3 post-OLT, n=3 controls), limiting generalizability.
Source
Post‐liver transplantation sarcopenia in cirrhosis: A prospective evaluation
Cynthia Tsien et al. · Journal of Gastroenterology and Hepatology · 2014
DOI 10.1111/jgh.12524
cohort · n=53Cited 181×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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