Research
Hormonal
Metformin treatment is associated with reduced cancer risk, potentially through AMPK activation and inhibition of mTOR.
Metformin is associated with reduced cancer risk in diabetic patients, possibly via AMPK/mTOR pathways. This is a potential therapeutic avenue, not a lifestyle recommendation.
GoodSupportsHIGH confidence
recent clinical studies have revealed that treatment with the biguanide metformin, a first-line treatment for patients with type 2 diabetes, is significantly associated with reduced cancer risk
Why this rating
Cited clinical studies show significant association, but the paper is a review.
Source
Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer
Javier A. Menéndez et al. · Clinical Chemistry · 2009
DOI 10.1373/clinchem.2008.115352
narrative_reviewCited 181×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Deregulation of fatty acid synthase (FASN)-catalyzed de novo fatty acid biogenesis drives a 'lipogenic state' that links insulin resistance, type 2 diabetes, and cancer.Moderate
- Pharmacological inhibition of FASN activity may prevent or reverse insulin-related metabolic disorders and reduce cancer risk.Moderate
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