Research
Macro partitioning
Saturated fatty acids (SFAs) promote inflammation and insulin resistance by activating TLR4 and inflammasomes, whereas polyunsaturated fatty acids (PUFAs) mitigate inflammation by suppressing NF-κB and upregulating anti-inflammatory IL-10.
Focus on the quality of your fats. Replace saturated fats (found in red meat, butter) with polyunsaturated fats (found in fish, nuts, olive oil). This shift can help lower inflammation and improve your body's sensitivity to insulin.
GoodSupportsHIGH confidence
Notably, FFAs play a dual role: saturated fatty acids (SFAs) activate TLR4 and inflammasomes to promote inflammation, while polyunsaturated fatty acids (PUFAs) mitigate it by suppressing NF-κB and upregulating anti-inflammatory IL-10.
Why this rating
Narrative review synthesizing mechanistic studies.
Source
The Mechanisms of Chronic Inflammation in Obesity and Potential Therapeutic Strategies: A Narrative Review
Elvira Meni Maria Gkrinia et al. · Current Issues in Molecular Biology · 2025
narrative_reviewCited 62×
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