Hormonal
Long-term high-protein diets significantly improve fasting insulin levels compared to low-protein diets, but this benefit disappears when only high-quality studies are analyzed.
You may see a small reduction in fasting insulin with a high-protein diet, but this does not guarantee better weight loss or health outcomes. Do not rely on high protein solely for insulin management, as the effect is inconsistent and not clinically significant in high-quality studies.
improvements of fasting insulin was significantly more pronounced following high protein diets as compared to the low protein counterparts (weighted mean difference: -0.71 μIU/ml, 95% CI −1.36 to −0.05, p = 0.03).
Why this rating
Statistically significant in primary analysis but lost in sensitivity analysis of high-quality RCTs.
Source
Long-term effects of low-fat diets either low or high in protein on cardiovascular and metabolic risk factors: a systematic review and meta-analysis
Lukas Schwingshackl et al. · Nutrition Journal · 2013
DOI 10.1186/1475-2891-12-48
More from this paper
- Long-term high-protein diets (≥25% energy) do not provide superior weight loss, fat loss, or cardiovascular risk reduction compared to low-protein diets when both are low-fat.Good
- High-protein diets significantly increase HDL cholesterol compared to low-protein diets, but only when studies involving Type 2 Diabetics are excluded.Moderate
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