Hormonal
Physical exercise induces white-to-brown adipose tissue conversion via the release of irisin and natriuretic peptides, offering a metabolic benefit independent of cold exposure.
Regular physical exercise does more than burn calories in the moment; it signals your body to convert energy-storing white fat into energy-burning brown-like fat. This happens through hormones like irisin released by muscles and natriuretic peptides from the heart. Consistent exercise can thus improve your metabolic health and resistance to obesity over time.
Physical exercise... induces an increase in hypothalamic BDNF activates the sympathetic nervous system, and is able to induce browning of the adipose organ... a recently discovered hormone called irisin, which is produced by murine and human skeletal muscles during physical exercise, has been proven to be a potent inducer of white-to-brown conversion
Why this rating
Strong mechanistic evidence in mice; human data is emerging but less definitive regarding magnitude of effect.
Source
The adipose organ: white‐brown adipocyte plasticity and metabolic inflammation
Arianna Smorlesi et al. · Obesity Reviews · 2012
DOI 10.1111/j.1467-789x.2012.01039.x
More from this paper
- Hypertrophic white adipocytes in obesity trigger chronic low-grade inflammation via macrophage infiltration, contributing to insulin resistance.Good
- Chronic cold exposure induces white-to-brown adipocyte transdifferentiation, increasing energy expenditure and protecting against obesity and type 2 diabetes.Moderate
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