Hormonal
Treatment with omega-3 polyunsaturated fatty acids (specifically EPA and DHA) suppresses macrophage inflammation by activating the AMPK/SIRT1 pathway, which deacetylates the NF-kB subunit p65 and inhibits its signaling.
This research explains the biological mechanism behind why omega-3s (EPA/DHA) are considered anti-inflammatory: they activate cellular energy sensors (AMPK/SIRT1) that turn off inflammatory signals (NF-kB). While this is a cellular study, it supports the general recommendation of omega-3s for managing inflammation, particularly in the context of metabolic health.
Our study defines AMPK/SIRT1 as a novel cellular mediator for the anti-inflammatory effects of v-3 PUFAs.
Why this rating
The study uses cell culture models (in vitro) and knockdown techniques, lacking human clinical trial data.
Source
Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway
Bingzhong Xue et al. · PLoS ONE · 2012
DOI 10.1371/journal.pone.0045990
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