Hormonal
Increased levels of specific fatty acid metabolites (3-hydroxylaurate, 3-hydroxyoctanoate, 3-hydroxydecanoate, 3-hydroxymyristate) and decreased levels of 1,5-anhydroglucitol (1,5-AG) and dimethylarginine (ADMA+SDMA) are associated with disease progression from insulin resistance to Type 2 Diabetes.
For individuals with obesity and insulin resistance, monitoring specific fatty acid metabolites and 1,5-AG levels may provide early warning signs of progression to Type 2 Diabetes. Decreasing 1,5-AG and increasing certain hydroxy-fatty acids are associated with this progression, suggesting these could be valuable markers for early intervention.
Figure 2 demonstrates patterns of increased (3-hydroxy-3-hydrocyoctanoate, 3-hydroxylaurate, 3-hydroxydecanoate, 3-hydroxymyristate, and glucose) or decreased (1,5-AG, ADMA + SDMA, homoarginine, ornithine, 2-oxoarginine) metabolites with disease progression.
Why this rating
Based on a pilot observational study with small group sizes and cross-sectional data.
Source
Metabolic signature of obesity-associated insulin resistance and type 2 diabetes
Haya Al‐Sulaiti et al. · Journal of Translational Medicine · 2019
DOI 10.1186/s12967-019-2096-8
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →