Hormonal
Higher TSH levels within the normal (euthyroid) range are associated with increased odds of prevalent metabolic syndrome, primarily driven by higher triglycerides and lower HDL cholesterol.
If you are in the older adult demographic and have metabolic syndrome risk factors, check your TSH even if it falls within the standard 'normal' lab range. Higher TSH within that normal window is linked to worse lipid profiles (high triglycerides, low HDL). This suggests that thyroid health extends beyond just treating overt hypothyroidism.
In fully adjusted models, each unit increase in TSH was associated with a 3% increase in the odds of prevalent metabolic syndrome... the association was stronger for TSH within the normal range (OR, 1.16; 95% CI, 1.03–1.30; P = 0.02)... The relationship between thyroid function and MetS appears to be driven primarily by higher triglycerides and lower HDL.
Why this rating
Prospective cohort study with large sample size and multivariable adjustment, but observational design limits causal inference.
Source
Thyroid function and prevalent and incident metabolic syndrome in older adults: the health, ageing and body composition study
Avantika C. Waring et al. · Clinical Endocrinology · 2011
DOI 10.1111/j.1365-2265.2011.04328.x
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