Hormonal

Administration of Meteorin-like protein (METRNL) attenuates lipid-induced inflammation and insulin resistance in skeletal muscle by activating AMPK and PPARδ signaling pathways, leading to increased fatty acid oxidation and reduced pro-inflammatory cytokine expression.

This research suggests that the metabolic benefits of exercise are partly driven by specific proteins (like METRNL) released by muscles, which directly improve insulin sensitivity and reduce inflammation. While this specific protein is not yet a commercial supplement, the finding supports the importance of resistance training and physical activity for managing metabolic health, independent of weight loss or calorie counting.