Hormonal
Tirzepatide slows the rate of eGFR decline in patients with type 2 diabetes, including those with preserved kidney function (eGFR >60 mL/min/1.73 m2) and normoalbuminuria.
Even if your kidney function tests are currently normal, tirzepatide can help protect your kidneys from future decline. Clinical data shows that this medication slows the rate of kidney function loss compared to insulin, regardless of whether you currently have signs of kidney disease. This makes it a valuable preventive tool for long-term kidney health in people with type 2 diabetes.
Tirzepatide also slowed the loss of eGFR, including participants that did not meet either the eGFR or the albuminuria KDIGO criterion for chronic kidney disease (CKD)
Why this rating
Based on post hoc analysis of SURPASS-4, showing dose-response in eGFR slope reduction.
Source
Tirzepatide and prevention of chronic kidney disease
Catalina Bosch et al. · Clinical Kidney Journal · 2022
DOI 10.1093/ckj/sfac274
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