Hormonal
In healthy centenarians, a higher plasma IGF-I/IGFBP-3 molar ratio is significantly associated with improved insulin action (higher whole body glucose disposal) and a more favorable lipid profile (lower triglycerides, free fatty acids, and LDL cholesterol).
For those seeking longevity, maintaining a healthy body composition and insulin sensitivity appears linked to a favorable IGF-I/IGFBP-3 balance. While you cannot directly 'dose' this ratio, the findings suggest that preserving insulin sensitivity and managing body fat may help maintain this hormonal balance, which is associated with better metabolic health in extreme old age.
In conclusion, healthy centenarians have plasma IGF-I/IGFBP-3 molar ratios greater than aged subjects. A more elevated plasma IGF-I/IGFBP-3 molar ratio might improve insulin action and plasma lipid concentration in centenarians.
Why this rating
The study is observational and cross-sectional with a small sample size (n=19 centenarians), limiting causal inference.
Source
Serum Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 in Healthy Centenarians: Relationship with Plasma Leptin and Lipid Concentrations, Insulin Action, and Cognitive Function
Giuseppe Paolisso et al. · The Journal of Clinical Endocrinology & Metabolism · 1997
DOI 10.1210/jcem.82.7.4087
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →