Hormonal
Two weeks of muscle disuse (via limb immobilization) impairs the muscle protein synthetic response to dietary protein ingestion, contributing to muscle atrophy.
If you are immobilized or have significantly reduced activity for two weeks, your muscles become less responsive to the protein you eat. This 'anabolic resistance' means you lose muscle faster than expected, even if you eat normally. To mitigate this, you may need to adjust your nutrition strategy (e.g., higher protein doses or specific amino acids) rather than just maintaining your usual diet, as your muscles are temporarily less able to build tissue from standard protein intake.
A short period of muscle disuse impairs the muscle protein synthetic response to dietary protein intake in vivo in healthy young men. Thus, anabolic resistance to protein ingestion contributes significantly to the loss of muscle mass that is observed during disuse.
Why this rating
Randomized controlled trial design with stable isotope tracing, though small sample size (n=12) and short duration limit generalizability.
Source
Disuse Impairs the Muscle Protein Synthetic Response to Protein Ingestion in Healthy Men
Benjamin T. Wall et al. · The Journal of Clinical Endocrinology & Metabolism · 2013
DOI 10.1210/jc.2013-2098
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