Hormonal
Enobosarm, a selective androgen receptor modulator (SARM), prevents and treats muscle wasting in cancer patients by increasing lean body mass and physical function without the androgenic side effects of traditional anabolic agents.
If you have advanced lung cancer and are starting chemotherapy, ask your doctor about Enobosarm. It is a drug designed to build muscle without the harsh side effects of older steroids. The standard dose is 3mg taken once a day for about 5 months. The goal is to keep your muscle mass from dropping and help you stay physically active.
Selective androgen receptor modulators (SARMs) have the potential to increase lean body mass (LBM) and hence muscle mass, without the untoward side effects seen with traditional anabolic agents.
Why this rating
The paper describes the design of Phase 3 trials (POWER 1 and 2) which are randomized, double-blind, and placebo-controlled, but results are not yet published.
Source
Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)
Jeffrey Crawford et al. · Current Oncology Reports · 2016
DOI 10.1007/s11912-016-0522-0
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