Research
Hormonal
Bupropion-naltrexone combination therapy produces significant weight loss (approx. 6%) by interrupting the cycle of addictive over-eating through synergistic appetite suppression.
If you struggle with addictive eating patterns or intense cravings, bupropion-naltrexone may be a suitable option. It works by suppressing appetite synergistically. Discuss potential side effects like constipation or anxiety with your doctor.
GoodSupportsHIGH confidence
The bupropion-naltrexone-combination appears promising for interruption of the vicious cycle of addictive over-eating.
Why this rating
Supported by phase-3 studies cited.
Source
Diets and drugs for weight loss and health in obesity – An update
Jan Aaseth et al. · Biomedicine & Pharmacotherapy · 2021
DOI 10.1016/j.biopha.2021.111789
narrative_reviewCited 174×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1 agonists (semaglutide and liraglutide) produce significant weight loss (approx. 8-16%) and improve glycemic control in obese patients, particularly those with type 2 diabetes or insulin resistance.Good
- Low-carbohydrate diets (LCDs) and low-fat diets (LFDs) result in equivalent weight loss when caloric restriction is matched, though LCDs may be preferred for patients with insulin resistance.Good
Related findings · Hormonal
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