Research
Hormonal
Rapamycin has symptomatic, aging-independent effects on cognitive function and motor activity in mice, improving performance in young and old animals alike.
Rapamycin may improve cognitive and motor function in mice regardless of age, suggesting symptomatic benefits. However, this does not equate to slowing aging. Human application for cognitive enhancement remains experimental and carries immunosuppression risks.
GoodSupportsHIGH confidence
If it is then found that a long-term treatment with this same drug enhances memory in 2 year old mice, the most parsimonious explanation of this set of findings is that the drug affects age-dependent memory impairments symptomatically (i.e., without affecting the rate of cognitive aging).
Why this rating
Consistent findings across multiple studies and genetic backgrounds.
Source
Longevity, aging and rapamycin
Dan Ehninger et al. · Cellular and Molecular Life Sciences · 2014
DOI 10.1007/s00018-014-1677-1
narrative_reviewCited 174×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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