Hormonal
In nonobese women with PCOS, combining ethinylestradiol-drospirenone with flutamide-metformin reverts adipocytokine balance and body composition toward normal, improving long-term cardiovascular perspectives.
For women with PCOS who are at risk of pregnancy, combining a standard oral contraceptive (ethinylestradiol-drospirenone) with low-dose flutamide (62.5 mg) and metformin (850 mg) daily for 9 months can significantly improve body composition and metabolic markers. This approach offers the benefits of pregnancy protection along with the metabolic advantages of insulin sensitization and androgen blockade.
ethinylestradiol-drospirenone plus flutamide-metformin, however, is a first OC combination that was found capable of reverting both the adipocytokine balance and the body composition toward normal, and that may therefore improve the long-term cardiovascular perspectives of women with PCOS.
Why this rating
Randomized controlled trial, open-labeled, small sample size (n=22 for women).
Source
Ethinylestradiol-Drospirenone, Flutamide-Metformin, or Both for Adolescents and Women with Hyperinsulinemic Hyperandrogenism: Opposite Effects on Adipocytokines and Body Adiposity
Lourdes Ibáñez et al. · The Journal of Clinical Endocrinology & Metabolism · 2004
DOI 10.1210/jc.2003-031281
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