Research
Hormonal
Deficiency in Stearoyl-CoA desaturase 1 (SCD1) improves insulin sensitivity and glucose tolerance in skeletal muscle.
Insulin resistance is linked to how fats are processed in the body. Studies in mice show that reducing SCD1 activity improves how muscles respond to insulin and handles glucose. This suggests that targeting SCD1 could be a strategy for managing type 2 diabetes and insulin resistance.
ModerateSupportsMEDIUM confidence
Mice with a targeted disruption of the SCD1 gene show improved glucose tolerance compared with wild-type mice, despite lower fasting plasma insulin levels.
Why this rating
Based on murine models showing elevated insulin signaling components.
Source
Stearoyl‐CoA desaturase as a new drug target for obesity treatment
Agnieszka Dobrzyń et al. · Obesity Reviews · 2005
DOI 10.1111/j.1467-789x.2005.00177.x
narrative_reviewCited 173×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Pharmacological inhibition or genetic deficiency of Stearoyl-CoA desaturase 1 (SCD1) reduces body adiposity and prevents diet-induced obesity by increasing energy expenditure and fatty acid oxidation.Moderate
- Inhibition of Stearoyl-CoA desaturase 1 (SCD1) protects against hepatic steatosis (fatty liver) by decreasing de novo fatty acid synthesis and increasing fatty acid oxidation.Moderate
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