Hormonal
Vitamin D3 supplementation does not significantly improve arterial stiffness, as measured by pulse wave velocity (PWV) or augmentation index (AI).
Do not expect vitamin D3 supplementation to directly improve arterial stiffness (PWV or AI). While it may help lower blood pressure and cholesterol, it does not appear to change the physical stiffness of your arteries. Manage arterial health through exercise, blood pressure control, and other lifestyle factors.
There was no significant effect of vitamin D supplementation on PWV (SMD = −0.20 ± 0.13 m/s, 95% CI, −0.46 to 0.06, p = 0.14) and AI (SMD = −0.09 ± 0.14%, 95% CI, −0.37 to 0.19, p = 0.52) for vitamin D supplemented groups.
Why this rating
Based on the same high-quality meta-analysis of 81 RCTs, providing robust evidence for the lack of effect on these specific metrics.
Source
Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis
Naghmeh Mirhosseini et al. · Frontiers in Cardiovascular Medicine · 2018
DOI 10.3389/fcvm.2018.00087
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