Research
Macro partitioning
Adipose tissue hypoxia initiates a local inflammatory response that is necessary for angiogenesis and the maintenance of a healthy adipose microenvironment during expansion.
Understanding that inflammation is part of the body's attempt to support expanding fat tissue (via new blood vessels) may help contextualize why 'anti-inflammatory' approaches might not work for weight loss.
ModerateSupportsMEDIUM confidence
In obesity, inflammation is initiated by a local hypoxia to augment angiogenesis and improve adipose tissue blood supply. A growing body of evidence suggests that macrophages and proinflammatory cytokines are essential for adipose remodeling and adipocyte differentiation.
Why this rating
Supported by animal studies showing hypoxia and angiogenesis markers, but human interventional data is limited.
Source
Inflammation during obesity is not all bad: evidence from animal and human studies
Jianping Ye et al. · American Journal of Physiology-Endocrinology and Metabolism · 2012
DOI 10.1152/ajpendo.00266.2012
narrative_reviewCited 172×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Chronic low-grade inflammation in obesity serves a beneficial physiological function by increasing energy expenditure and promoting adipose tissue remodeling, thereby limiting adiposity and improving glucose homeostasis.Moderate
- Proinflammatory cytokines such as TNF-alpha, IL-1, IL-6, and leptin contribute to increased energy expenditure and reduced food intake, which counteracts obesity.Moderate
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