Hormonal
Acute vigorous submaximal exercise (67% VO2max for 60 minutes) significantly increases circulating GDF15 levels in humans, with levels continuing to rise during the recovery period.
Performing vigorous exercise (around 67% of your max capacity) for an hour triggers a significant rise in GDF15, a hormone linked to appetite suppression and energy balance. This rise continues for at least two hours after you stop exercising. While this doesn't mean your muscles are releasing the hormone directly, the systemic effect is real and substantial.
Vigorous submaximal exercise increases circulating GDF15 levels in humans... Plasma GDF15 levels increased 34% with exercise (p<0.001) and further increased to 64% above resting values at 120 min (p<0.001) after the cessation of exercise.
Why this rating
Small sample size (n=7) and short duration limit generalizability, but the within-subject controlled design and rigorous sampling (arterial/venous) provide high internal validity.
Source
Exercise increases circulating GDF15 in humans
Maximilian Kleinert et al. · Molecular Metabolism · 2018
DOI 10.1016/j.molmet.2017.12.016
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →