Hormonal
Weekly subcutaneous administration of IBI362, a GLP-1 and glucagon receptor dual agonist, produces significant body weight loss and improves metabolic parameters in Chinese adults with overweight or obesity.
IBI362 is a once-weekly injection that helps overweight and obese Chinese adults lose weight and improve metabolic health. It works by targeting two hormones (GLP-1 and glucagon) to reduce appetite and increase energy expenditure. In this study, participants lost between 4.8% and 6.4% of their body weight over 12 weeks, with side effects like nausea being mostly mild. This suggests it is a viable option for those seeking pharmacological weight loss support.
IBI362 was well tolerated and showed a body weight-lowering effect in Chinese adults with overweight or obesity.
Why this rating
Phase 1b study with small sample size (n=36) and short duration (12 weeks), but randomized and placebo-controlled.
Source
IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study
Linong Ji et al. · EClinicalMedicine · 2021
DOI 10.1016/j.eclinm.2021.101088
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