Hormonal
Circulating PCSK9 exhibits a diurnal rhythm that parallels cholesterol synthesis (measured by lathosterol) but does not correlate with stable serum LDL levels.
PCSK9 levels fluctuate throughout the day in sync with how much cholesterol your liver is making, not necessarily with the amount of LDL in your blood. This means PCSK9 is a marker of liver cholesterol synthesis activity, not a direct predictor of your circulating LDL levels.
serum PCSK9 levels display a diurnal rhythm that closely parallels that of cholesterol synthesis, measured as serum lathosterol... serum low-density lipoprotein (LDL) cholesterol levels remained stable during the diurnal cycle.
Why this rating
Consistent findings across multiple subjects and time points.
Source
Circulating Proprotein Convertase Subtilisin Kexin Type 9 Has a Diurnal Rhythm Synchronous With Cholesterol Synthesis and Is Reduced by Fasting in Humans
Lena Persson et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2010
DOI 10.1161/atvbaha.110.214130
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