Hormonal
Long-term calorie restriction (30% reduction) slows the age-related decline of serum dehydroepiandrosterone sulfate (DHEAS) in adult rhesus monkeys, serving as a biomarker for slowed aging.
In rhesus monkeys, restricting calories by 30% significantly slowed the natural age-related drop in DHEAS, a hormone linked to aging. This suggests that caloric restriction may preserve hormonal health and slow aging processes in primates, though direct human application requires further study.
Most important is the finding that, in rhesus monkeys, calorie restriction, which extends life span and retards aging in laboratory rodents, slows the postmaturational decline in serum DHEAS levels.
Why this rating
Longitudinal study in non-human primates with controlled diet, though limited to male monkeys for the CR group and short duration (3-6 years).
Source
Dehydroepiandrosterone Sulfate: A Biomarker of Primate Aging Slowed by Calorie Restriction
Mark A. Lane et al. · The Journal of Clinical Endocrinology & Metabolism · 1997
DOI 10.1210/jcem.82.7.4038
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