Research

Macro partitioning

Adherence to a Mediterranean or Okinawan dietary pattern, characterized by high whole-grain intake and a low protein-to-carbohydrate ratio (significantly less than 1), reduces cardiovascular mortality and slows aging progression.

To support longevity, prioritize a dietary pattern like the Mediterranean or Okinawan diet. This involves eating plenty of whole grains, vegetables, and legumes while keeping the ratio of protein to carbohydrates low (less than 1:1). Focus on whole grains rather than refined grains to maximize fiber and nutrient intake.

ModerateSupportsMEDIUM confidence
A regular physical activity and a regular intake of whole grain derivatives together with the optimization of the protein/carbohydrate ratio in the diet, where the ratio is significantly less than 1 such as in the Mediterranean diet and the Okinawan diet, reduces the risk of developing aging-related diseases and increases healthy life expectancy.
Cristiano Capurso · Nutrients · 2021

Why this rating

The paper is a review of cohort and case-control studies, not a randomized controlled trial.

Source

Whole-Grain Intake in the Mediterranean Diet and a Low Protein to Carbohydrates Ratio Can Help to Reduce Mortality from Cardiovascular Disease, Slow Down the Progression of Aging, and to Improve Lifespan: A Review

Cristiano Capurso · Nutrients · 2021

DOI 10.3390/nu13082540

narrative_reviewCited 53×
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DOI resolved against Crossref · corpus check 2026-06-10

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