Research
Adherence
Circadian misalignment, such as night-shift work or irregular eating patterns, impairs hepatic metabolic function and increases the risk of developing NAFLD and insulin resistance.
Maintain a consistent sleep-wake cycle and try to align your eating window with your active hours. Disrupting your body's internal clock (e.g., through night shifts or late-night eating) can worsen insulin resistance and increase the risk of fatty liver, even if your diet is otherwise healthy.
GoodSupportsHIGH confidence
Epidemiologic studies show that circadian misalignment increases the risk of developing metabolic diseases such as obesity, type 2 diabetes, and NAFLD in night-shift workers... harmful effects on postprandial glucose and insulin levels were observed in controlled circadian misalignment models, which indicated decreased insulin sensitivity after disruption of the circadian clock.
Why this rating
Supported by epidemiological studies and controlled mouse models.
Source
Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease
Hsu‐Wen Chao et al. · International Journal of Molecular Sciences · 2019
DOI 10.3390/ijms20020298
narrative_reviewCited 170×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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