Research
Hormonal
Melatonin deficiency or dysfunction is associated with a wide range of diseases beyond sleep disorders, including dementia, mood disorders, cancer, diabetes type 2, and severe pain.
Low melatonin levels are a common feature in many chronic conditions, including diabetes, cancer, and dementia. While treating the underlying disease is primary, addressing melatonin deficiency may support overall health and sleep.
GoodSupportsMEDIUM confidence
Reduced melatonin levels are also observed in various diseases, such as types of dementia, some mood disorders, severe pain, cancer, and diabetes type 2.
Why this rating
The paper is a review summarizing associations, noting that causality is not always established.
Source
Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction
Rüdiger Hardeland · The Scientific World JOURNAL · 2012
DOI 10.1100/2012/640389
narrative_reviewCited 170×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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