Hormonal
In nondiabetic men with coronary artery disease, higher intake of saturated fatty acids is independently associated with elevated fasting insulin concentrations, indicating a direct link to insulin resistance separate from obesity.
For men with known heart disease, high intake of saturated fats is linked to higher insulin levels, a marker of insulin resistance, regardless of body weight. While this study is observational, it suggests that reducing saturated fat may support better metabolic health in this specific group.
These cross-sectional findings in nondiabetic men with coronary artery disease suggest that increased consumption of saturated fatty acids is associated independently with higher fasting insulin concentrations.
Why this rating
Cross-sectional design prevents causal inference; self-reported dietary data introduces bias; however, the sample is specific and adjusted for confounders.
Source
Saturated fat intake and insulin resistance in men with coronary artery disease. The Stanford Coronary Risk Intervention Project Investigators and Staff.
David J. Maron et al. · Circulation · 1991
DOI 10.1161/01.cir.84.5.2020
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