Hormonal
Adipose tissue NAPE-PLD is essential for the browning process of white adipose tissue; its deletion impairs cold-induced thermogenesis and reduces the expression of browning markers like Ucp1 and Ppargc1a.
Your fat cells can be stimulated to burn more energy, a process called 'browning.' This study shows that specific signaling molecules in fat are required for this process. When these signals are missing, your body struggles to generate heat and burn fat, even in cold conditions. Maintaining healthy fat tissue signaling may support your body's ability to regulate energy expenditure.
We report that Napepld-deleted mice present an altered browning programme and are less responsive to cold-induced browning, highlighting the essential role of NAPE-PLD in regulating energy homeostasis and metabolism in the physiological state.
Why this rating
Strong mechanistic evidence using cold exposure challenges and gene expression analysis.
Source
Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
Lucie Geurts et al. · Nature Communications · 2015
DOI 10.1038/ncomms7495
More from this paper
- Deletion of the endocannabinoid-synthesizing enzyme NAPE-PLD specifically in adipose tissue causes obesity, glucose intolerance, and insulin resistance in mice, primarily through impaired adipose browning and altered gut microbiota composition.Good
- The metabolic phenotype caused by adipose NAPE-PLD deletion is mediated by changes in gut microbiota composition, as evidenced by the partial transfer of the obese and insulin-resistant phenotype to germ-free mice via fecal microbiota transplantation.Good
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