Hormonal
In older men with diabetes, treatment with insulin sensitizers (metformin and/or thiazolidinediones) significantly attenuates the accelerated loss of total and appendicular lean mass compared to untreated diabetes or diabetes treated without insulin sensitizers.
If you are an older man with diabetes, ask your doctor if your current medication is an 'insulin sensitizer' like metformin or a thiazolidinedione. This study suggests these drugs may help protect your muscle mass from the accelerated loss often seen in diabetes. If you are not on one, or are on other diabetes meds, discuss whether switching to or adding an insulin sensitizer might help preserve your strength and mobility.
Skeletal muscle loss was accelerated in men with IFG and diabetes, except when the latter was treated with insulin sensitizers. These findings suggest that insulin sensitizers may attenuate muscle loss.
Why this rating
Observational cohort study with large sample size but potential for residual confounding by indication.
Source
Insulin Sensitizers May Attenuate Lean Mass Loss in Older Men With Diabetes
Christine G. Lee et al. · Diabetes Care · 2011
DOI 10.2337/dc11-1032
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →