Hormonal
Higher expression of the cardiolipin synthase gene CRLS1 in human subcutaneous adipose tissue is positively correlated with insulin sensitivity and negatively correlated with insulin resistance.
In humans, higher levels of the enzyme that makes cardiolipin (CRLS1) in belly fat are linked to better insulin sensitivity. This suggests that supporting the health of this enzyme might be beneficial for metabolic health, although the exact way to do this is not yet defined.
CRLS1 mRNA levels in human scWAT negatively correlated with HOMA2 measures of insulin resistance and positively correlated with HOMA2 measures of insulin sensitivity.
Why this rating
Strong correlation in human cohorts, but causality is not fully established due to potential tissue-wide effects of genetic variants.
Source
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
Elahu G. Sustarsic et al. · Cell Metabolism · 2018
DOI 10.1016/j.cmet.2018.05.003
More from this paper
- Synthesis of the mitochondrial phospholipid cardiolipin (CL) in brown and beige fat is essential for systemic energy homeostasis, insulin sensitivity, and metabolic flexibility.Good
- Disruption of cardiolipin synthesis in thermogenic fat leads to insulin resistance and reduced metabolic flexibility through a mechanism involving ER stress factor CHOP-10.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →