Hormonal

Higher circulating levels of specific trans fatty acids (t-16:1n9 and t-18:1) are positively associated with an increased risk of incident type 2 diabetes in older adults, but this association is largely explained by their correlation with de novo lipogenesis (DNL) markers rather than a direct causal effect of the trans fats themselves.

Focus on overall dietary quality rather than fixating solely on trans fats. This study suggests that high levels of certain circulating fatty acids, which are linked to how your body produces its own fats (de novo lipogenesis), are associated with higher diabetes risk. Since dietary self-reports didn't show a clear link, prioritizing whole foods, fiber, and healthy fats (like those in fish and nuts) is likely more effective for diabetes prevention than just avoiding processed foods with trans fats.