Adherence
Intensified Health Education (IHE) comprising dietary advice, physical activity promotion, and smoking/alcohol cessation significantly improves glycemic control and reduces the need for antidiabetic drugs in newly diagnosed NIDDM patients, but fails to prevent cardiovascular complications or improve lipid profiles.
For newly diagnosed type 2 diabetics, structured education on diet quality, exercise, and smoking cessation significantly improves blood sugar control and delays the need for medication. However, this approach alone does not prevent heart attacks or lower cholesterol, suggesting that additional medical interventions (like lipid-lowering drugs) may be necessary for cardiovascular protection.
IHE resulted in improved glucose control (adjusted fasting blood glucose) levels after 5 yr... The better glycemic control was achieved with fewer antidiabetic drugs... However, IHE had no effect on calorie intake, percentage of fat in the diet (45%), and body weight... The most important finding was the significant increase of blood cholesterol in all three groups... Clofibric acid only prevented the increase of triglyceride levels... The incidence rate per 1000 for myocardial infarction was 30.3 for control subjects, 53.6 for the IHE group, and 55.6 for the IHE plus clofibric acid group.
Why this rating
Large-scale (n=1139), randomized, 5-year multi-intervention trial with rigorous follow-up.
Source
Diabetes Intervention Study: Multi-Intervention Trial in Newly Diagnosed NIDDM
M Hanefeld et al. · Diabetes Care · 1991
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