Adherence
Higher cumulative smoking dosage (pack-years) is directly associated with increased serum levels of biomarkers for DNA damage and telomere dysfunction, independent of chronological age.
Smoking accelerates biological aging markers in your blood. The more you smoke and the longer you smoke, the higher these markers go, regardless of your age. The best way to lower these specific DNA damage markers is to stop smoking.
The study shows that lifestyle factors have an age-independent impact on the expression level of biomarkers of DNA damage. Smoking and increased body mass indices were associated with elevated levels of biomarkers of DNA damage independent of the age of the individuals.
Why this rating
Observational cohort study with a reasonably large sample size (n=103 for smoking analysis) and robust statistical correction for age, though causality is inferred rather than proven via RCT.
Source
Lifestyle impacts on the aging‐associated expression of biomarkers of DNA damage and telomere dysfunction in human blood
Zhangfa Song et al. · Aging Cell · 2010
DOI 10.1111/j.1474-9726.2010.00583.x
More from this paper
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- Higher Body Mass Index (BMI) is directly associated with increased serum levels of biomarkers for DNA damage and telomere dysfunction, independent of chronological age.Good
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