Research
Adherence
The deleterious effects of total sitting time on HDL cholesterol, triglycerides, and post-load glucose become significantly more severe as the duration of uninterrupted sitting bouts increases.
Be aware that sitting for long periods (e.g., >30 mins) is worse for your cholesterol and blood sugar than sitting for the same total time in shorter chunks. If you have a long meeting or drive, try to break it up if possible to mitigate the metabolic impact.
GoodQualifiesHIGH confidence
Significant interactions (p<0.05) showed that associations of sitting time with HDL, triglycerides and PLG became more deleterious the longer at a time sitting was usually accumulated.
Why this rating
Statistically significant interaction effects found using high-validity measures.
Source
Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults
John Bellettiere et al. · PLoS ONE · 2017
DOI 10.1371/journal.pone.0180119
cross_sectional · n=678Cited 167×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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