Hormonal
In women with PCOS, the risk of Type 2 Diabetes Mellitus (T2DM) is primarily driven by overweight and obesity rather than the syndrome itself; normal-weight women with PCOS do not have an increased risk of T2DM or prediabetes.
If you have PCOS, your weight is the most critical factor in your diabetes risk. If you are overweight or obese, you are at significantly higher risk, but this risk is driven by the weight, not just the PCOS diagnosis. If you are normal weight, your risk of developing Type 2 Diabetes is not significantly higher than women without PCOS. Focus on maintaining a healthy weight, especially during early adulthood, as this is the most effective way to prevent diabetes in PCOS.
The risk of T2DM in women with PCOS is mainly due to overweight and obesity... Normal weight women with PCOS did not present with an increased risk of prediabetes or T2DM.
Why this rating
Prospective, population-based cohort study with long-term follow-up (32 years) and clinical OGTT verification, though PCOS diagnosis was self-reported.
Source
Overweight and obese but not normal weight women with PCOS are at increased risk of Type 2 diabetes mellitus—a prospective, population-based cohort study
Meri‐Maija Ollila et al. · Human Reproduction · 2016
DOI 10.1093/humrep/dew329
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