Research
Hormonal
Leptin resistance in obesity is driven by impaired transport of leptin across the blood-brain barrier, largely due to saturation by high endogenous levels and inhibition by hypertriglyceridemia.
High blood triglycerides can block leptin from reaching the brain. Managing blood fats may help improve leptin sensitivity.
GoodSupportsHIGH confidence
It is generally assumed that this impairment of transport results from a saturation of the leptin transporter due to the high endogenous leptin levels of these mice... hypertriglyceridemia markedly impairs it.
Why this rating
Supported by studies on blood-brain barrier transport mechanisms in rodents and humans.
Source
Leptin and the Control of Body Weight: A Review of Its Diverse Central Targets, Signaling Mechanisms, and Role in the Pathogenesis of Obesity
Ashwini Oswal et al. · Obesity · 2009
DOI 10.1038/oby.2009.228
narrative_reviewCited 166×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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