Research
Hormonal
Caffeine ingestion (5 mg/kg) does not improve maximal anaerobic power or capacity during the Wingate Test in untrained subjects, despite increasing catecholamine and lactate levels.
If you are not a trained athlete, taking 5mg/kg of caffeine before a short, high-intensity effort (like a 30-second sprint) is unlikely to improve your performance. While it will increase your stress hormones and lactate, it won't make you faster or stronger in that specific context.
ModerateRefutesMEDIUM confidence
Caffeine administration did not significantly change either maximal anaerobic capacity (AC) or power (AP) and power decrease (PD)... These data suggest that caffeine, essentially via epinephrine, modifies glycolytic metabolism but fails to improve performance during the Wingate Anaerobic Test in nonspecifically trained subjects.
Why this rating
Small sample size (n=6), single session, untrained subjects; limits generalizability.
Source
Effects of Caffeine Ingestion on Performance and Anaerobic Metabolism during the Wingate Test
Katia Collomp et al. · International Journal of Sports Medicine · 1991
DOI 10.1055/s-2007-1024710
crossover · n=6Cited 166×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →