Research
Hormonal
Immobilization significantly reduces the phosphorylation of mTOR at 48 hours, indicating early suppression of anabolic signaling, which correlates with the down-regulation of PGC-1alpha and mitochondrial biogenesis.
Early in immobilization, your body's primary anabolic signaling (mTOR) is suppressed, which likely contributes to the shutdown of mitochondrial function. This suggests that early nutritional or pharmacological interventions targeting mTOR might be most effective in preserving metabolic health during the first few days of inactivity.
GoodSupportsHIGH confidence
mTOR phosphorylation decreased significantly following 48 H of immobilization but not 14 D... PGC-1a, the master regulator of mitochondrial biogenesis, was down-regulated at both 48 H and 14 D along with dozens of downstream PGC-1a targets
Why this rating
Measured via Western blotting in the same cohort.
Source
Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women
Arkan Abadi et al. · PLoS ONE · 2009
DOI 10.1371/journal.pone.0006518
rct · n=24Cited 187×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Two weeks of unilateral limb immobilization induces a coordinate down-regulation of mitochondrial bioenergetic and carbohydrate metabolism pathways in human skeletal muscle, leading to significant reductions in muscle strength and cross-sectional area.Good
- Protein ubiquitination and the expression of atrogenes (atrogin-1, MuRF-1) are significantly increased early (48 hours) during immobilization but return to baseline levels by 14 days, suggesting a transient role for this pathway in short-term human muscle atrophy.Good
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