Research
Hormonal
The acute post-exercise increase in Interleukin-6 (IL-6) is correlated with muscle hypertrophy, but it does not add predictive value beyond local muscle factors like AR and p70S6K.
The inflammatory response to exercise, specifically IL-6, is correlated with muscle growth. However, this is likely a byproduct of local muscle adaptation rather than the primary driver. Focus on training consistency rather than trying to manipulate inflammation.
GoodQualifiesHIGH confidence
the magnitude of the post exercise IL-6 response was correlated with muscle hypertrophy (r=0.48, P=0.019).
Why this rating
Prospective study with cytokine measurements.
Source
Muscular and Systemic Correlates of Resistance Training-Induced Muscle Hypertrophy
Cameron J. Mitchell et al. · PLoS ONE · 2013
DOI 10.1371/journal.pone.0078636
cohort · n=23Cited 183×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Acute post-exercise increases in systemic hormones (testosterone, GH, IGF-1) are not related to muscle hypertrophy following resistance training.Good
- Intramuscular factors, specifically changes in Androgen Receptor (AR) protein content and p70S6K phosphorylation, are significant predictors of muscle hypertrophy, explaining more variance than systemic hormones.Good
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