Research
Hormonal
A 12-week treatment with dulaglutide prevents post-cessation weight gain in the short term (12 weeks), but this benefit is lost after discontinuation, resulting in similar weight gain to placebo at 52 weeks.
Dulaglutide can help you avoid gaining weight during your first 12 weeks of quitting smoking. However, once you stop the injections, you will likely gain weight similar to someone not taking the drug. To maintain weight loss, you may need to stay on the medication longer than 12 weeks.
StrongQualifiesHIGH confidence
Post-cessation weight gain was prevented in the dulaglutide group (−1.0 kg, standard deviation [SD] 2.7) as opposed to the placebo group (+1.9 kg, SD 2.4) after 12 weeks... at week 52 the groups showed similar weight gain... baseline-adjusted difference in weight change: −0.35 kg (95% CI [−1.72, 1.01]).
Why this rating
Same high-quality RCT design as Node 1.
Source
Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trial
H Lüthi et al. · EClinicalMedicine · 2024
DOI 10.1016/j.eclinm.2024.102429
rct · n=255Cited 37×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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