Hormonal
Semaglutide 2.4 mg administered once weekly for 6 months produces a mean body weight reduction of 10.5 kg (10.0%) in adults with obesity or overweight, with 79% of patients achieving clinically significant weight loss (≥5%).
If you have obesity or overweight with a related health condition, semaglutide 2.4 mg taken once weekly can help you lose an average of 10% of your body weight over 6 months. This is significantly more effective than diet and exercise alone for many people. You should discuss with your doctor if this treatment is appropriate for you, especially if you haven't used other weight-loss medications before.
After 6 months, mean body weight change was −10.5 ± 6.8 kg ... and mean percentage body weight change was −10.0% ± 6.6% ... Most (79.0%) patients had ≥5% body weight reduction
Why this rating
The study is a retrospective observational cohort study using real-world claims data, which establishes association but not causation and lacks a control group.
Source
Semaglutide 2.4 mg clinical outcomes in patients with obesity or overweight in a real‐world setting: A 6‐month retrospective study in the United States (SCOPE)
Aleksandrina Ruseva et al. · Obesity Science & Practice · 2024
DOI 10.1002/osp4.737
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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