Hormonal
The co-ingestion of protein and calcium produces a synergistic, potent stimulation of endogenous GLP-1 secretion that exceeds the effects of either nutrient alone.
To maximize your body's natural appetite-suppressing hormone (GLP-1), combine protein and calcium in your meals. Research shows this combination triggers a much stronger hormonal response than eating protein or calcium alone. This is a natural, side-effect-free way to support satiety and metabolic health.
Emerging evidence suggests the synergy of protein and calcium could also act as a potent secretagogue of GLP-1... In the most recent human study, this synergy produced some of the highest reported concentrations of GLP-1 following physiological ingestion to date.
Why this rating
Supported by multiple human studies showing high GLP-1 concentrations, though the narrative review nature limits causal certainty compared to RCTs.
Source
Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review
Jonathan Watkins et al. · Advances in Nutrition · 2021
DOI 10.1093/advances/nmab078
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →