Hormonal
Semaglutide administration reduces visceral fat accumulation and improves glucose intolerance in obese mice by downregulating key lipogenic proteins (CD36, FABP5, ACSL, PLIN2) in epididymal white adipose tissue.
In this mouse study, semaglutide reduced fat mass by altering how fat cells store and process lipids, specifically by downregulating proteins like CD36 and PLIN2. This suggests that GLP-1 therapies may have direct peripheral effects on fat tissue metabolism, not just central appetite control. For humans, this supports the use of GLP-1 agonists for obesity management, though human dosing and response may vary.
Bioinformatics analysis showed a reduction of CD36, FABP5, ACSL, ACOX3, PLIN2, ANGPTL4, LPL, MGLL, AQP7, and PDK4 involved in the lipid metabolism in the Sema group accompanied by a decrease in visceral fat accumulation, blood lipids, and improvement in glucose intolerance.
Why this rating
High-quality proteomic data (TMT/LC-MS/MS) in a controlled animal model, but results are not directly translatable to humans without clinical trials.
Source
Proteomic analysis reveals semaglutide impacts lipogenic protein expression in epididymal adipose tissue of obese mice
Ruiyi Zhu et al. · Frontiers in Endocrinology · 2023
DOI 10.3389/fendo.2023.1095432
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