Research
Macro partitioning
Semaglutide therapy alters energy partitioning, resulting in a greater proportion of fat-free mass loss relative to fat loss compared to predictions based on standard energy density models.
Semaglutide may cause you to lose more muscle mass relative to fat than standard dieting. Ensure you are consuming adequate protein and engaging in resistance training to mitigate this specific side effect.
ModerateQualifiesMEDIUM confidence
This indicated a possible semaglutide-induced alteration in energy partitioning... a greater than expected proportion of fat-free mass was lost with semaglutide treatment
Why this rating
Derived from model fitting to observed DXA data, requiring parameter adjustment.
Source
Physiology of the weight‐loss plateau in response to diet restriction, <scp>GLP‐1</scp> receptor agonism, and bariatric surgery
Kevin D. Hall · Obesity · 2024
DOI 10.1002/oby.24027
mechanism_onlyCited 32×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Macro partitioning
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