Research
Hormonal
Phentermine/topiramate combination therapy results in significant weight loss but is associated with increased heart rate and potential psychiatric side effects.
Phentermine/topiramate is a combination pill that can lead to significant weight loss. However, it can increase your heart rate and cause psychiatric side effects like anxiety or depression. It requires careful monitoring by a doctor, and if you don't lose enough weight after a few months, the treatment may be stopped.
GoodQualifiesHIGH confidence
The combination results with more weight loss compared with its monotherapy components (PHEN/TPM 15/92 mg −11.63 kg vs phentermine 15 mg −7.38 kg, topiramate 92 mg −8.82 kg, p<0.05)... Adverse effects include dry mouth, psychiatric side effects including depression, anxiety and loss of concentration. Studies also reported increased heart rate with PHEN/TPM.
Why this rating
Based on randomized controlled trials and meta-analyses.
Source
Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview
Özge Telci Çaklılı et al. · Diabetes Metabolic Syndrome and Obesity · 2023
DOI 10.2147/dmso.s392684
narrative_reviewCited 30×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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