Hormonal
The exponential decay of energy intake suppression during obesity pharmacotherapy is caused by a physiological proportional feedback control system that increases appetite in proportion to weight loss, rather than a diminishing direct effect of the drug itself.
If you are taking obesity medication and your weight loss slows down after a few months, it is likely due to your body's natural physiological resistance to losing weight, not necessarily because the drug has stopped working. This is a predictable part of the process described by proportional feedback control. Maintaining the medication as prescribed may still be beneficial for long-term weight management, even if the rate of loss decreases.
the exponential decay over time of obesity pharmacotherapies to suppress energy intake can be interpreted as a relatively constant effect of each drug superimposed on a physiological feedback control system regulating body weight.
Why this rating
The evidence is based on a mathematical model fitted to retrospective data from 14 drug trials, showing good predictive power (70% variance explained) but with noted biases and outliers.
Source
Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy
Kevin D. Hall et al. · Obesity · 2017
DOI 10.1002/oby.21978
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